Article
Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response.
Oncogene - 7 Jan 1999
Korpelainen E I, Kärkkäinen M, Gunji Y, Vikkula M, Alitalo K
Abstract excerpt
Endothelial receptor tyrosine kinases (RTKs) and their signaling mechanisms are of interest because they may control tumor angiogenesis and thereby tumor growth. In this report we have examined activation of the signal transducers and activators of transcription (STATs) by the three known vascula...
Topics
- Cell Line, Transformed
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA-Binding Proteins
- Endothelium, Vascular
- Enzyme Activation
- Gene Expression
- Humans
- Milk Proteins
- Mutation
- Proto-Oncogene Proteins
- Receptor Protein-Tyrosine Kinases
- Receptor, TIE-2
- STAT1 Transcription Factor
- STAT3 Transcription Factor
- STAT5 Transcription Factor
- Signal Transduction
- Trans-Activators