Article
Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism.
Atherosclerosis - 1 Jul 2007
Henneman Peter, Schaap Frank G, Havekes Louis M, Rensen Patrick C N, Frants Rune R, van Tol Arie, Hattori Hiroaki, Smelt August H M, van Dijk Ko Willems
Abstract excerpt
OBJECTIVE: The recently discovered apoAV is hypothesized to affect triglyceride metabolism by stimulating the lipolysis of triglycerides in VLDL and chylomicrons. We set out to determine the association between increased serum TG levels, plasma apoAV levels, and polymorphism of the APOA5 gene, with specific emphasis on the APOA5 S19W variation. This mutation alters the endoplasmic reticulum signal peptide and is...
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