Article
New DNA-analysis techniques (minireview).
Biomedica biochimica acta - 1 Jan 1991
Coutelle C
Abstract excerpt
The increasing knowledge about specific human genes and their alterations causing genetic diseases, requires new strategies and methods for mutation-detection. However, the large molecular heterogeneity of such mutations in each gene sets serious limitations to this approach. The polymerase chain reaction has become the basis of several new developments aiming to overcome this problem. Recently developed methods...
Topics
- Base Sequence
- DNA
- Electrophoresis
- Genetic Linkage
- Genetic Techniques
- Humans
- Mutation
- Nucleic Acid Hybridization
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length