Article
Phenotypic alterations induced by the Hong Kong-prevalent Epstein-Barr virus-encoded LMP1 variant (2117-LMP1) in nasopharyngeal epithelial cells.
International journal of cancer - 10 May 2004
Lo Angela Kwok Fung, Huang Dolly P, Lo Kwok Wai, Chui Yiu Loon, Li Hoi Ming, Pang Jesse Chung Sean, Tsao Sai-Wah
Abstract excerpt
Epstein-Barr virus (EBV) is closely associated with nasopharyngeal carcinoma (NPC), a common cancer in Hong Kong. The EBV-encoded LMP1 protein is believed to play an important role in cell transformation. We have previously identified a prevalent LMP1 variant (2117-LMP1) that is expressed in 86% of primary NPC in Hong Kong. In this study, the biologic phenotypes induced by 2117-LMP1 were compared with those of...
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