Article
DNA sequence analysis and restriction fragment length polymorphism (RFLP) typing of the HLA-DQw2 alleles associated with dermatitis herpetiformis.
The Journal of investigative dermatology - 1 Aug 1991
Otley C C, Wenstrup R J, Hall R P
Abstract excerpt
Dermatitis herpetiformis (DH) is a blistering autoimmune skin disease associated with a 95-100% incidence of the HLA class II antigen HLA-DQw2. Although the precise role of this antigen in the pathogenesis of DH is unclear, one theory proposes that patients with DH possess a molecularly unique subtype of the HLA-DQw2 antigen that causes immune abnormalities eventuating in the clinical manifestations of DH. To...
Topics
- Alleles
- Base Sequence
- Celiac Disease
- DNA
- Dermatitis Herpetiformis
- Exons
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- Humans
- Polymorphism, Restriction Fragment Length