Article
Polymorphism of the tumor necrosis factor genes in patients with dermatitis herpetiformis.
Dermatology (Basel, Switzerland) - 1 Jan 1994
Messer G, Kick G, Ranki A, Koskimies S, Reunala T, Meurer M
Abstract excerpt
In 18 patients with dermatitis herpetiformis (DH) of whom 16 were HLA-DR3 positive and 14 had the HLA-B8, -DR3 haplotype, the frequencies of known mutations of the tumor necrosis factor alpha (TNF-alpha) and TNF-beta genes were investigated using restriction fragment length polymorphism analysis and the single-strand conformational polymorphism technique. In DH, the phenotype frequency (28%) and allele frequency...
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