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Article

Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jun 2006

Wyrobek A J, Eskenazi B, Young S, Arnheim N, Tiemann-Boege I, Jabs E W, Glaser R L, Pearson F S, Evenson D

Abstract excerpt

This study compares the relative effects of advancing male age on multiple genomic defects in human sperm [DNA fragmentation index (DFI), chromatin integrity, gene mutations, and numerical chromosomal abnormalities], characterizes the relationships among these defects and with semen quality, and estimates the incidence of susceptible individuals for a well characterized nonclinical nonsmoking group of 97 men...

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Source

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Identifiers

PMID: 16766665
DOI: 10.1073/pnas.0506468103
PMCID: PMC1480453

Genes

FGFR2
FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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