A short amino acid sequence containing tyrosine in the N-terminal region of G protein-coupled receptors is critical for their potential use as co-receptors for human and simian immunodeficiency viruses.

Abstract excerpt

Various G protein-coupled receptors (GPCRs) have the potential to work as co-receptors for human and simian immunodeficiency virus (HIV/SIV). HIV/SIV co-receptors have several tyrosines in their extracellular N-terminal region (NTR) as a common feature. However, the domain structure of the NTR th...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to HIV-2
• Share to Receptors, CCR5
• Share to Receptors, G-Protein-Coupled