Induction of a mesencephalic phenotype in the 2-day-old chick prosencephalon is preceded by the early expression of the homeobox gene en.

doi:10.1016/0896-6273(91)90237-t

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Article

Induction of a mesencephalic phenotype in the 2-day-old chick prosencephalon is preceded by the early expression of the homeobox gene en.

Neuron - 1 Jun 1991

Martinez S, Wassef M, Alvarado-Mallart R M

Abstract excerpt

The homeobox gene en, homologous to the gene en-grailed of Drosophila, is expressed in the metencephalic-mesencephalic segment of the vertebrate neural tube. Using quail-chick chimeras, an antibody against en proteins, and cytoarchitectonic techniques, we demonstrate that metencephalon transplanted to prosencephalon, at E2, maintains a high level of en proteins and its presumptive cerebellar fate. The ectopic...

Topics

Animals
Antibodies, Monoclonal
Brain Tissue Transplantation
Chick Embryo
Chimera
Drosophila
Drosophila Proteins
Embryo, Nonmammalian
Fetal Tissue Transplantation
Gene Expression
Genes, Homeobox

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homeodomain Proteins

Insect Hormones

Mesencephalon

Phenotype

Pons

Quail

Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 1675863
DOI: 10.1016/0896-6273(91)90237-t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1675863-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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