Article
Several regions of Antennapedia and thyroid transcription factor 1 homeodomains contribute to DNA binding specificity.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 1991
Damante G, Di Lauro R
Abstract excerpt
The DNA binding specificities of the homeodomains contained in thyroid transcription factor 1 and Antennapedia have been compared. The two homeodomains recognize different DNA sequences, despite the similar amino acid sequences of their recognition helix. Mutations that make the recognition helix of thyroid transcription factor 1 identical to the one contained in Antennapedia have no effects on the binding...
Topics
- Amino Acid Sequence
- Base Sequence
- DNA
- Gene Expression Regulation
- Genes, Homeobox
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Thyroid Nuclear Factor 1
- Transcription Factors