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Article

Apoptotic cell death induction and angiogenesis inhibition in large established medullary thyroid carcinoma xenografts by Ret inhibitor RPI-1.

Biochemical pharmacology - 14 Aug 2006

Petrangolini Giovanna, Cuccuru Giuditta, Lanzi Cinzia, Tortoreto Monica, Belluco Sara, Pratesi Graziella, Cassinelli Giuliana, Zunino Franco

Abstract excerpt

Recent evidence indicates that the success of molecular targeted therapies may depend on the identification of drug targets which are essential for the survival of subsets of tumors. RET oncogenes that have been implicated in the development of thyroid carcinomas are emerging as potential therapeutic targets. In the present study, we investigated the efficacy and the cellular bases of antitumor activity of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16756963
DOI: 10.1016/j.bcp.2006.05.002

Genes

RET
BAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Apoptotic cell death induction and angiogenesis inhibition in large established medullary thyroid carcinoma xenografts by Ret inhibitor RPI-1.PMID 16756963Read ↗

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Targeting of RET oncogene by naphthalene diimide-mediated gene promoter G-quadruplex stabilization exerts anti-tumor activity in oncogene-addicted human medullary thyroid cancer.Semantic proximity Read ↗

Identification of RET kinase inhibitors as potential new treatment for sporadic and inherited thyroid cancer.Semantic proximity Read ↗

Inhibition of transforming activity of the ret/ptc1 oncoprotein by a 2-indolinone derivative.Semantic proximity Read ↗

A novel role for nonactin: interfering with G-quadruplex in RET-driven medullary thyroid cancer.Semantic proximity Read ↗

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The HIV protease inhibitor nelfinavir down-regulates RET signaling and induces apoptosis in medullary thyroid cancer cells.Semantic proximity Read ↗

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