Article
The HIV protease inhibitor nelfinavir down-regulates RET signaling and induces apoptosis in medullary thyroid cancer cells.
The Journal of clinical endocrinology and metabolism - 1 May 2014
Kushchayeva Yevgeniya, Jensen Kirk, Recupero Antony, Costello John, Patel Aneeta, Klubo-Gwiezdzinska Joanna, Boyle Lisa, Burman Kenneth, Vasko Vasyl
Abstract excerpt
CONTEXT: Mutations of RET tyrosine kinase are associated with the development of medullary thyroid cancer (MTC). The heat shock protein (HSP) 90 chaperone is required for folding and stability of RET mutants. HSP90 is a molecular target for the HIV protease inhibitor nelfinavir (NFV). OBJECTIVE: We hypothesized that treatment with NFV may lead to the inhibition of RET signaling and induction of apoptosis in MTC...
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