Article
Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q.
Molecular psychiatry - 1 Aug 2006
Shugart Y Y, Samuels J, Willour V L, Grados M A, Greenberg B D, Knowles J A, McCracken J T, Rauch S L, Murphy D L, Wang Y, Pinto A, Fyer A J, Piacentini J, Pauls D L, Cullen B, Page J, Rasmussen S A, Bienvenu O J, Hoehn-Saric R, Valle D, Liang K-Y, Riddle M A, Nestadt G
Abstract excerpt
Obsessive-compulsive disorder (OCD) is the tenth most disabling medical condition worldwide. Twin and family studies implicate a genetic etiology for this disorder, although specific genes have yet to be identified. Here, we present the first large-scale model-free linkage analysis of both extended and nuclear families using both 'broad' (definite and probable diagnoses) and 'narrow' (definite only) definitions...
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