Article
Minimal disease detection and confirmation in hematologic malignancies: combining cell sorting with clonality profiling.
Clinical chemistry - 1 Mar 2006
Zehentner Barbara K, Fritschle Wayne, Stelzer Tess, Ghirardelli Keely M, Hunter Kimberly, Wentzel Collette, Bennington Richard, Hansen Christian L, Myerson David, Kalnoski Michael, Wells Denise A, Loken Michael R
Abstract excerpt
BACKGROUND: In this study we demonstrate the technical application of flow cytometry and cell sorting combined with gene-rearrangement clonality profiling to detect and confirm minimal disease in 2 leukemia and 2 lymphoma cases. METHODS: Specimens with low percentages (0.05%-5%) of abnormal lymphoid populations were identified by flow cytometry. The abnormal lymphoid populations were sorted by flow cytometry, and...
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