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Article

Modulation of human immunodeficiency virus type 1 synergistic inhibition by reverse transcriptase mutations.

Biochemistry - 13 Jun 2006

Basavapathruni Aravind, Vingerhoets Johan, de Béthune Marie-Pierre, Chung Raymond, Bailey Christopher M, Kim Jiae, Anderson Karen S

Abstract excerpt

Synergy between the anti-human immunodeficiency virus type 1 (HIV) nucleoside reverse transcriptase (RT) inhibitors (NRTIs) and nonnucleoside RT inhibitors (NNRTIs) results from a general mechanism in which NNRTIs inhibit ATP-mediated removal of NRTIs from chain-terminated primers by decreasing the maximum rate of removal, thus sustaining NRTI chain termination. With this molecular mechanism of synergy,...

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PMID: 16752922
DOI: 10.1021/bi052362v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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