Article
Vasoactive intestinal polypeptide induces tyrosine hydroxylase in PC12 cells.
The Journal of biological chemistry - 25 May 1991
Wessels-Reiker M, Haycock J W, Howlett A C, Strong R
Abstract excerpt
Physiological stress induces tyrosine hydroxylase, the rate-limiting enzyme for catecholamine biosynthesis, via trans-synaptic mechanisms within the adrenal medulla. Previous studies have implicated cAMP as a second messenger capable of inducing tyrosine hydroxylase; however, it is unclear whether any receptor coupled to adenylate cyclase mediates tyrosine hydroxylase induction. Recently, vasoactive intestinal...
Topics
- Animals
- Blotting, Northern
- Chromatography, High Pressure Liquid
- Enzyme Induction
- Gene Expression Regulation, Enzymologic
- Mutation
- Protein Kinases
- RNA, Messenger
- Rats
- Tumor Cells, Cultured
- Tyrosine 3-Monooxygenase