Article
The neuropeptide VIP modulates the neurotransmitter phenotype of cultured chick sympathetic neurons.
Developmental biology - 1 Nov 1991
Beretta C, Zurn A D
Abstract excerpt
The present report provides evidence for a novel function for the neuropeptide vasoactive intestinal peptide (VIP). We demonstrate that VIP increases the cholinergic and the noradrenergic properties of cultured chick sympathetic neurons without changing neuronal survival and metabolism. VIP induces a 10- to 15-fold increase in the activity of choline acetyltransferase and an approximately twofold increase in the...
Topics
- Animals
- Cells, Cultured
- Chick Embryo
- Cyclic AMP
- Kinetics
- Neurons
- Neurotransmitter Agents
- Phenotype
- Sympathetic Nervous System
- Vasoactive Intestinal Peptide
