Article
Variation in the low density lipoprotein receptor gene is associated with differences in plasma low density lipoprotein cholesterol levels in young and old normal individuals from Italy.
Arteriosclerosis and thrombosis : a journal of vascular biology - 1 Jan 2000
Humphries S, Coviello D A, Masturzo P, Balestreri R, Orecchini G, Bertolini S
Abstract excerpt
We have used four restriction fragment length polymorphisms (RFLPs) of the human low density lipoprotein receptor (LDL-R) gene, detected by the restriction enzymes Ava II, Pvu II, and ApaLI (5' and 3'), to study the effect of variation at this gene locus in determining plasma cholesterol and LDL...
Topics
- Adult
- Aged
- Aging
- Cholesterol
- Cholesterol, LDL
- Deoxyribonucleases, Type II Site-Specific
- Genetic Variation
- Humans
- Italy
- Middle Aged
- Polymorphism, Restriction Fragment Length
- Receptors, LDL