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Article

Methylation of two Homo sapiens-specific X-Y homologous genes in Klinefelter's syndrome (XXY).

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jul 2006

Ross Norman L J, Wadekar Rekha, Lopes Alexandra, Dagnall Adam, Close James, Delisi Lynn E, Crow Timothy J

Abstract excerpt

An increased incidence of psychiatric and structural brain abnormalities in individuals with Klinefelter syndrome (KS, 47 XXY) could be due to the presence of extra copies of X-Y homologous genes that escape X inactivation. Of particular interest are the two brain-expressed genes Protocadherin11XY (PCDH11XY) and the Synaptobrevin-like gene (SYBL1) which have been duplicated from the X chromosome to the Y...

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PMID: 16741946
DOI: 10.1002/ajmg.b.30339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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