Article
A family-based and case-control association study of SOX10 in schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jul 2006
Iwamoto Kazuya, Bundo Miki, Yamada Kazuo, Takao Hitomi, Iwayama Yoshimi, Yoshikawa Takeo, Kato Tadafumi
Abstract excerpt
Downregulation of oligodendrocyte-related genes in postmortem brains of patients with schizophrenia has been reported by several DNA microarray studies. We recently reported that enhanced DNA methylation of SOX10, which encodes a transcription factor responsible for terminal differentiation of oligodendrocyte, correlated with lower expression of SOX10 and other oligodendrocyte-related genes. Although we ruled out...
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