Article
Genetic analysis of circulating and sequestered populations of Plasmodium falciparum in fatal pediatric malaria.
The Journal of infectious diseases - 1 Jul 2006
Montgomery Jacqui, Milner Danny A, Tse Man Tsuey, Njobvu Alfred, Kayira Kondwani, Dzamalala Charles P, Taylor Terrie E, Rogerson Stephen J, Craig Alister G, Molyneux Malcolm E
Abstract excerpt
Falciparum malaria is characterized by cytoadherence of host erythrocytes containing mature asexual-stage parasites and the consequent sequestration of these forms in tissue microvasculature. A postmortem study of pediatric malaria provided us with the opportunity to compare the genetic complexity of circulating and sequestered Plasmodium falciparum populations, in patients with fatal cerebral malaria (CM) versus...
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