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Human Papillomavirus Type 16 E7 Up-regulates AKT Activity through the Retinoblastoma Protein

1 Jun 2006

Abstract excerpt

Human papillomaviruses (HPV) are small DNA tumor viruses causally associated with cervical cancer. The early gene product E7 from high-risk HPV is considered the major transforming protein expressed by the virus. Although many functions have been described for E7 in disrupting normal cellular processes, we describe in this study a new cellular target in primary human foreskin keratinocytes (HFK), the...

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PMID: 16740689
DOI: 10.1158/0008-5472.can-06-0499

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