Article
A multimeric membrane protein reveals 14-3-3 isoform specificity in forward transport in yeast.
Traffic (Copenhagen, Denmark) - 1 Jul 2006
Michelsen Kai, Mrowiec Thomas, Duderstadt Karl E, Frey Steffen, Minor Daniel L, Mayer Matthias P, Schwappach Blanche
Abstract excerpt
Arginine (Arg)-based endoplasmic reticulum (ER) localization signals are sorting motifs involved in the quality control of multimeric membrane proteins. They are distinct from other ER localization signals like the C-terminal di-lysine [-K(X)KXX] signal. The Pmp2p isoproteolipid, a type I yeast membrane protein, reports faithfully on the activity of sorting signals when fused to a tail containing either an...
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