Article
[Genetic polymorphisms in the promoter region of cyclooxygenase-2 and their association with risk of gastric cancer].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae - 1 Apr 2006
Zhang Xue-mei, Miao Xiao-ping, Tan Wen, Sun Tong, Guo Yong-li, Zhao Dan, Lin Dong-xin
Abstract excerpt
OBJECTIVE: To examine the genetic polymorphisms in the promoter region of cyclooxygenase-2 ( COX-2) and evaluate their association with the risk of gastric cancer. METHODS: Single-strand conformational polymorphism and DNA sequencing were used to screen the genetic variants of the COX-2 promoter region. Total 323 patients with gastric cancer and 646 frequency-matched controls were genotyped by polymerase chain...
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