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Ganglioglioma arising in a Peutz-Jeghers patient: a case report with molecular implications.

Acta neuropathologica - 1 Jul 2006

Resta Nicoletta, Lauriola Libero, Puca Alfredo, Susca Francesco C, Albanese Alessio, Sabatino Giovanni, Di Giacomo Marilena C, Gessi Marco, Guanti Ginevra

Abstract excerpt

The Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder caused by inactivating germline mutations in the serine-threonine kinase gene LKB1, is characterized by mucocutaneous pigmentation, multiple gastrointestinal hamartomatous polyps, and by an increased risk for developing tumors involving several different organs. To date, no brain tumors have been described in PJS patients. In this report, we...

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PMID: 16733653
DOI: 10.1007/s00401-006-0084-6

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