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Article

Genetic heterogeneity in Peutz-Jeghers syndrome

1 Jan 2000

Abstract excerpt

LKB1, the human gene encoding a serine threonine kinase, was recently identified as a susceptibility gene for Peutz-Jeghers syndrome (PJS), a disease characterized by the constellation of intestinal hamartomata, oral mucocutaneous hyperpigmentation, and an increased risk for gastrointestinal as well as extraintestinal malignancies. To date, the majority of individuals with PJS have been found to have genetic...

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PMID: 10874301
DOI: 10.1002/1098-1004(200007)16:1<23::aid-humu5>3.0.co;2-m

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