Article
A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genes.
Experimental cell research - 1 Aug 2006
Sandoval Raudel, Xue Jiaping, Tian Xinyong, Barrett Kelly, Pilkinton Mark, Ucker David S, Raychaudhuri Pradip, Kineman Rhonda D, Luque Raul M, Baida Gleb, Zou Xianghong, Valli V E, Cook James L, Kiyokawa Hiroaki, Colamonici Oscar R
Abstract excerpt
It has been proposed that C. elegans LIN-9 functions downstream of CDK4 in a pathway that regulates cell proliferation. Here, we report that mammalian BARA/LIN-9 is a predominantly nuclear protein that inhibits cell proliferation. More importantly, we demonstrate that BARA/LIN-9 also acts downstream of cyclin D/CDK4 in mammalian cells since (i) its antiproliferative effect is partially blocked by coexpression of...
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