Article
Abdominal fat accumulation in adults born preterm exposed antenatally to maternal glucocorticoid treatment is dependent on glucocorticoid receptor gene variation.
The Journal of clinical endocrinology and metabolism - 1 Oct 2011
Finken Martijn J J, Meulenbelt Ingrid, Dekker Friedo W, Frölich Marijke, Walther Frans J, Romijn Johannes A, Slagboom P Eline, Wit Jan M
Abstract excerpt
CONTEXT: Preterm birth is associated with short stature, abdominal adiposity, insulin resistance, and hypertension, resembling effects of increased glucocorticoid bioactivity. Although antenatal glucocorticoid treatment does not substantially contribute to these associations, it is unknown whether genetic variants in the glucocorticoid receptor gene could modulate the effects of antenatal glucocorticoid treatment...
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