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Article

Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling.

Molecular and cellular biology - 1 Jun 2006

Ishida-Takahashi Ryoko, Rosario Felicia, Gong Yusong, Kopp Keely, Stancheva Zlatina, Chen Xiaohong, Feener Edward P, Myers Martin G

Abstract excerpt

The leptin receptor, LRb, and other cytokine receptors are devoid of intrinsic enzymatic activity and rely upon the activity of constitutively associated Jak family tyrosine kinases to mediate intracellular signaling. In order to clarify mechanisms by which Jak2, the cognate LRb-associated Jak kinase, is regulated and mediates downstream signaling, we employed tandem mass spectroscopic analysis to identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16705160
DOI: 10.1128/MCB.01589-05
PMCID: PMC1489076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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