Monosomy for the X-Chromosome Is Associated with an Atherogenic Lipid Profile

Abstract excerpt

CONTEXT AND OBJECTIVE: Men typically have a more atherogenic lipid profile than women characterized by higher low-density lipoprotein (LDL) cholesterol and triglyceride levels and reduced lipid particle size, contributing to a greater risk for coronary disease. To determine whether X-chromosomal gene dosage affects lipid metabolism independent of sex steroid effects, we compared lipid profiles in age- and body...

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• Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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