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Nobiletin, a citrus flavonoid, suppresses phorbol ester‐induced expression of multiple scavenger receptor genes in THP‐1 human monocytic cells

4 May 2006

Abstract excerpt

Unregulated uptake of oxidized low-density lipoproteins (ox-LDL) via macrophage scavenger receptors (SRs) such as lectin-like ox-LDL receptor-1 (LOX-1) is a key event in atherosclerosis. In this study, we examined the effects of five selected food phytochemicals on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced LOX-1 mRNA expression in THP-1 human monocyte-like cells. Nobiletin, a citrus polymethoxylated...

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Identifiers

PMID: 16698017
DOI: 10.1016/j.febslet.2006.04.077

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