Article
Influence of genotype, dose and sex on pruritogen-induced scratching behavior in the mouse.
Pain - 1 Sept 2006
Green Amanda D, Young Katrina K, Lehto Sonya G, Smith Shad B, Mogil Jeffrey S
Abstract excerpt
Itch features considerable interindividual variability in humans, and initial studies using animal models have demonstrated a likely role of genetic factors in mediating such variability. In an attempt to systematically study genetic mediation of itch in the mouse such that gene identification by linkage mapping might be achieved, we examined scratching behavior induced by histamine and chloroquine in mice of 11...
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