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Article

Allelic silencing at the tumor-suppressor locus 13q14.3 suggests an epigenetic tumor-suppressor mechanism.

Proceedings of the National Academy of Sciences of the United States of America - 16 May 2006

Mertens Daniel, Wolf Stephan, Tschuch Cordula, Mund Cora, Kienle Dirk, Ohl Sibylle, Schroeter Petra, Lyko Frank, Döhner Hartmut, Stilgenbauer Stephan, Lichter Peter

Abstract excerpt

Genomic material from chromosome band 13q14.3 distal to the retinoblastoma locus is recurrently lost in a variety of human neoplasms, indicating an as-yet-unidentified tumor-suppressor mechanism. No pathogenic mutations have been found in the minimally deleted region until now. However, in B cell chronic lymphocytic leukemia tumors with loss of one copy of the critical region, respective candidate...

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Share to Chromosomes, Human, Pair 13
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16684883
DOI: 10.1073/pnas.0600494103
PMCID: PMC1472515

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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