Article
Analysis of gene mutations in four cases of dermatofibrosarcoma protuberans.
Clinical and experimental dermatology - 1 May 2006
Saeki H, Tamada Y, Watanabe D, Akita Y, Matsumoto Y, Imai C, Kadono T, Maekawa T, Hattori N, Watanabe A, Torii H, Tamaki K
Abstract excerpt
Fusion of the collagen type I alpha 1 (COL1A1) gene with the platelet-derived growth factor B-chain (PDGFB) gene has been described in dermatofibrosarcoma protuberans (DFSP). Various exons of the COL1A1 gene have been shown to be involved in the fusion with exon 2 of the PDGFB gene. We examined the breakpoints of the COL1A1 gene using the tumour specimens from four patients with DFSP. The COL1A1-PDGFB fusion...
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