Article
Analysis of gene mutations in three cases of dermatofibrosarcoma protuberans (DFSP): ordinary DFSP, DFSP with fibrosarcomatous lesion (DFSP-FS) and lung metastasis of DFSP-FS.
Journal of dermatological science - 1 Dec 2003
Saeki Hidehisa, Hoashi Toshihiko, Tada Yayoi, Ashida Ryuichi, Kuwano Yoshihiro, Le Pavoux Andre, Tsunemi Yuichiro, Shikada Junichiro, Torii Hideshi, Kawabata Yasuhiro, Kikuchi Kanako, Tamada Yasuhiko, Matsumoto Yoshinari, Tamaki Kunihiko
Abstract excerpt
BACKGROUND: Fusion of the collagen type I alpha 1 (COL1A1) gene with the platelet-derived growth factor B-chain (PDGFB) gene has been pointed out in dermatofibrosarcoma protuberans (DFSP). Various exons of the COL1A1 gene have been shown to be involved in the fusion with exon 2 of the PDGFB gene. OBJECTIVE: We studied the breakpoints of the COL1A1 gene using the tumor specimens from three patients with DFSP....
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