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Article

A Novel Chromosomal Translocation Associated WithCOL1A2-PDGFBGene Fusion in Dermatofibrosarcoma Protuberans

2 Sept 2015

Abstract excerpt

IMPORTANCE: Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer that develops in the deep dermis to subcutaneous adipose tissues. A COL1A1-PDGFB gene fusion, leading to the constitutive expression of PDGFB, is the tumorigenic mechanism in most DFSP cases. OBJECTIVES: To evaluate the specificity of PDGFB expression as a diagnostic marker of DFSP and to determine whether other pathomechanisms (ie, gene...

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Identifiers

PMID: 26332510
DOI: 10.1001/jamadermatol.2015.2389

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