Article
Segregation analysis of a complex quantitative trait: approaches for identifying influential data points.
Human heredity - 1 Jan 2006
Igo Robert P, Chapman Nicola H, Wijsman Ellen M
Abstract excerpt
BACKGROUND/AIMS: Complex traits pose a particular challenge to standard methods for segregation analysis (SA), and for such traits it is difficult to assess the ability of complex SA (CSA) to approximate the true mode of inheritance. Here we use an oligogenic Bayesian Markov chain Monte Carlo method for SA (OSA) to verify results from a single-locus likelihood-based CSA for data on a quantitative measure of...
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