Article
Vertebrate DNA transposon as a natural mutator: the medaka fish Tol2 element contributes to genetic variation without recognizable traces.
Molecular biology and evolution - 1 Jul 2006
Koga Akihiko, Iida Atsuo, Hori Hiroshi, Shimada Atsuko, Shima Akihiro
Abstract excerpt
DNA-based transposable elements, or DNA transposons, transpose in a cut-and-paste fashion, involving excision from the chromosome. If this process affects the function of a host gene and the excision rate is high, any gene associated with such an element would clearly be in a genetically "unstable" state, and there are many examples of unstable genes in various organisms. However, none have hitherto been reported...
Topics
- Alleles
- Animals
- Base Sequence
- Blotting, Southern
- Breeding
- DNA
- DNA Transposable Elements
- Embryo, Nonmammalian
- Female
- Gene Frequency
- Genetic Variation
- Male
- Molecular Sequence Data
- Mutagenesis, Insertional