Article
Reversion mutation of ib oculocutaneous albinism to wild-type pigmentation in medaka fish.
Pigment cell research - 1 Oct 2005
Iida Atsuo, Takamatsu Naofumi, Hori Hiroshi, Wakamatsu Yuko, Shimada Atsuko, Shima Akihiro, Koga Akihiko
Abstract excerpt
We have previously identified three naturally occurring mutations in the medaka fish tyrosinase gene caused by transposable element insertions. Tyr-i(b) is one of these, containing the Tol2 element in the promoter region. Its homozygous carriers exhibit a weak oculocutaneous albino phenotype. We report here spontaneous reversion of the albino phenotype to the wild-type pigmentation, associated with excision of...
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