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Article

Development of a serum-free co-culture of human intestinal epithelium cell-lines (Caco-2/HT29-5M21)

2 May 2006

Abstract excerpt

BACKGROUND: The absorptive and goblet cells are the main cellular types encountered in the intestine epithelium. The cell lineage Caco-2 is a model commonly used to reproduce the features of the bowel epithelium. However, there is a strong debate regarding the value of Caco-2 cell culture to mimick in vivo situation. Indeed, some authors report in Caco-2 a low paracellular permeability and an ease of access of...

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PMID: 16670004
DOI: 10.1186/1471-2121-7-20

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