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Evaluation of Caco-2 and human intestinal epithelial cells as in vitro models of colonic and small intestinal integrity

18 Jul 2022

Abstract excerpt

Although the colonic cell line Caco-2 is widely used as a model of the small intestinal barrier function, it has limitations such as overestimated transepithelial electrical resistance (TEER) compared to in vivo conditions. Therefore, we investigated Human Intestinal Epithelial Cells (HIECs) as an alternative in vitro model . We explored whether cell seeding number of HIEC-6, and the number of incubation days for...

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PMID: 35873654
DOI: 10.1016/j.bbrep.2022.101314

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