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Article

Epigenetic Inactivation of <i>Betaig-h3</i> Gene in Human Cancer Cells

1 May 2006

Abstract excerpt

Gene silencing by CpG island methylation in the promoter region is one of the mechanisms by which tumor suppressor genes are inactivated in human cancers. It has been shown previously that Betaig-h3 gene, which encodes an extracellular matrix protein involved in cell adhesion and tumorigenesis, is down-regulated or silenced in a variety of human cancer cell lines. To unravel the underlying molecular mechanism(s)...

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PMID: 16651406
DOI: 10.1158/0008-5472.can-05-2130

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