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Article

A major genetic locus controlling natural Plasmodium falciparum infection is shared by East and West African Anopheles gambiae.

Malaria journal - 6 Jul 2007

Riehle Michelle M, Markianos Kyriacos, Lambrechts Louis, Xia Ai, Sharakhov Igor, Koella Jacob C, Vernick Kenneth D

Abstract excerpt

BACKGROUND: Genetic linkage mapping identified a region of chromosome 2L in the Anopheles gambiae genome that exerts major control over natural infection by Plasmodium falciparum. This 2L Plasmodium-resistance interval was mapped in mosquitoes from a natural population in Mali, West Africa, and controls the numbers of P. falciparum oocysts that develop on the vector midgut. An important question is whether...

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Identifiers

PMID: 17612409
DOI: 10.1186/1475-2875-6-87
PMCID: PMC1936428

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