Article
Matrix metalloproteinase-1 and -9 promoter polymorphisms are not associated with an increased risk of uterine leiomyomas in a Japanese population.
Journal of the Society for Gynecologic Investigation - 1 Apr 2006
Takemura Naoya, Yoshida Shigeki, Kennedy Stephen, Deguchi Masashi, Ohara Noriyuki, Maruo Takeshi
Abstract excerpt
OBJECTIVE: Matrix metalloproteinases (MMPs) play an important role in modeling and remodeling the extracellular matrix in leiomyomas. Hence, we investigated whether associations exist between leiomyomas and promoter polymorphisms in the MMP-1 and MMP-9 genes in a Japanese population. METHODS: We compared the distribution of polymorphisms in the promoter regions of MMP-1 (-1607 1G/2G) and MMP-9 (-1562 C/T) in 267...
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