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Article

GATA1 mutations in acute leukemia in children with Down syndrome.

Cancer genetics and cytogenetics - 15 Apr 2006

Magalhães Isis Quezado, Splendore Alessandra, Emerenciano Mariana, Figueiredo Alexandre, Ferrari Iris, Pombo-de-Oliveira Maria S

Abstract excerpt

It has been reported that somatic mutations in the X-linked GATA1 gene are present in hematological clonal disorders in children with Down syndrome (DS). We analyzed retrospective samples of DS children with acute myeloid leukemia, transient leukemia (TL), and myelodysplastic syndrome (MDS) to test whether the specificity of GATA1 mutations can be helpful in distinguishing these hematopoietic disorders. A total...

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Source

Identifiers

PMID: 16631466
DOI: 10.1016/j.cancergencyto.2005.10.008

Genes

GATA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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