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Article

Functional impact of HIV coreceptor-binding site mutations.

Virology - 20 Jul 2006

Biscone Mark J, Miamidian John L, Muchiri John M, Baik Sarah S W, Lee Fang-Hua, Doms Robert W, Reeves Jacqueline D

Abstract excerpt

The bridging sheet region of the gp120 subunit of the HIV-1 Env protein interacts with the major virus coreceptors, CCR5 and CXCR4. We examined the impact of mutations in and adjacent to the bridging sheet region of an X4 tropic HIV-1 on membrane fusion and entry inhibitor susceptibility. When the V3-loop of this Env was changed so that CCR5 was used, the effects of these same mutations on CCR5 use were assayed...

Read the complete abstract on PubMed

Topics

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Share to Enfuvirtide
Share to HIV-1
Share to HIV Envelope Protein gp120

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Envelope Protein gp41

Share to HIV Fusion Inhibitors

Share to Membrane Fusion

Share to Peptide Fragments

Share to Receptors, HIV

Source

Identifiers

PMID: 16631222
DOI: 10.1016/j.virol.2006.03.017

Genes

CCR5
CXCR4
CCR3
CCR8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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