Article
Zebrafish msxB, msxC and msxE function together to refine the neural-nonneural border and regulate cranial placodes and neural crest development.
Developmental biology - 15 Jun 2006
Phillips Bryan T, Kwon Hye-Joo, Melton Colt, Houghtaling Paul, Fritz Andreas, Riley Bruce B
Abstract excerpt
The zebrafish muscle segment homeobox genes msxB, msxC and msxE are expressed in partially overlapping domains in the neural crest and preplacodal ectoderm. We examined the roles of these msx genes in early development. Disrupting individual msx genes causes modest variable defects, whereas disrupting all three produces a reproducible severe phenotype, suggesting functional redundancy. Neural crest...
Topics
- Animals
- Cell Proliferation
- Cell Survival
- Embryo, Nonmammalian
- Embryonic Structures
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- In Situ Hybridization
- Neural Crest
- Neurons
- Oligonucleotides, Antisense
- Phenotype
- Transcription Factors