Article
Joint effect among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate cancer risk: an exploratory genotype-environment interaction study.
Asian journal of andrology - 1 May 2006
Quiñones Luis A, Irarrázabal Carlos E, Rojas Claudio R, Orellana Cristian E, Acevedo Cristian, Huidobro Christian, Varela Nelson E, Cáceres Dante D
Abstract excerpt
AIM: To assess the role of several genetic factors in combination with an environmental factor as modulators of prostate cancer risk. We focus on allele variants of low-penetrance genes associated with cell control, the detoxification processes and smoking. METHODS: In a case-control study we compared people carrying p53cd72 Pro allele, CYP1A1 M1 allele and GSTM1 null genotypes with their prostate cancer risk....
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