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Mutations in DNA binding domain of p53 impede RSL1D1-p53 interaction to escape from degradation in human colorectal cancer cells.

Experimental cell research - 1 Aug 2022

Ding Li, Zhao Chenhong, Xu Yujie, Zhang Zhiping, Nie Yesen, Liao Kai, Chen Yuerou, Tu Beibei, Zhang Xinyue

Abstract excerpt

Different from the nucleolus-specific localization in some types of cancer cells, ribosomal L1 domain-containing protein 1 (RSL1D1) distributes throughout the nucleus in human colorectal cancer (CRC) cells. RSL1D1 directly interacts with DNA binding domain (aa 93-292) of wild-type p53 (p53-WT) and thereby recruits p53 to HDM2. The ensuing formation of RSL1D1/HDM2/p53 complex enhances p53 ubiquitination and...

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PMID: 35597299
DOI: 10.1016/j.yexcr.2022.113211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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