Article
Beta-sitosterol-3-O-beta-D-glucopyranoside: a eukaryotic DNA polymerase lambda inhibitor.
The Journal of steroid biochemistry and molecular biology - 1 May 2006
Mizushina Yoshiyuki, Nakanishi Rumi, Kuriyama Isoko, Kamiya Kohei, Satake Toshiko, Shimazaki Noriko, Koiwai Osamu, Uchiyama Yukinobu, Yonezawa Yuko, Takemura Masaharu, Sakaguchi Kengo, Yoshida Hiromi
Abstract excerpt
Beta-sitosterol-3-O-beta-D-glucopyranoside (compound 1), a steroidal glycoside isolated from onion (Allium cepa L.) selectively inhibited the activity of mammalian DNA polymerase lambda (pol lambda) in vitro. The compound did not influence the activities of replicative DNA polymerases such as alpha, delta and epsilon, but also showed no effect even on the activity of pol beta which is thought to have a very...
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